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Calpain activation has been demonstrated to cleave myelin proteins including myelin basic protein and myelin-associated glycoprotein [51] and contribute to myelin disruption in animal models for spinal cord injury [52] and MS [53].
More specifically, severe thoracic lesions result in permanent paralysis of hind limbs in rodents, which have been extensively used as models for spinal cord injury in humans.
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The molecular regulation and cellular changes found in salmon vertebral fusions are similar to those found in mammalian deformities, showing that salmon is suitable for studying general bone development and to be a comparative model for spinal deformities.
The fusion process involves molecular regulation and cellular changes similar to those found in mammalian deformities, indicating that salmon is suitable for studying general bone development and to be a comparative model for spinal deformities.
In humans and in a mouse model for spinal cord lesion, upregulation of FAS ligand (FASLG) is required for the recruitment of peripheral myeloid cells to the injured tissue [ 31].
In an experimental model for spinal cord compression, exposure of juxtaparanodal Kv1.2 channels with accompanying myelin retraction at the nodes contributed to the induction of conduction block (Ouyang et al., 2010).
Conversely to these theoretical extrapolations the same author reports further experimental data [ 45] which show contradictory results, in particular reliability of the LQ model for spinal cord as late reacting tissue with a fractionation dose up to 10 Gy.
Hence, there is a relative paucity of mouse models for isolated spinal NTDs, despite the importance of these malformations in humans.
However, there is no practical and clinically relevant mouse model available for spinal cord ischemia.
Zebrafish larvae are an ideal model organism for modeling spinal cord injury (SCI) and the subsequent biochemical response because of the unique ability to regenerate.
Kwon, B.K. et al. Large animal and primate models of spinal cord injury for the testing of novel therapies.
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