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The resulting QSAR models for rat and human H3 binding affinities were validated using different strategies.
Surprisingly, there has not yet been a careful assessment of the performance of the different pharmacokinetic models for rat studies.
This leads to a large set of possible models, 579 models for rat 1 and 683 models for rat 2.
The log-likelihood distributions for all models for rat 1 and rat 2 are shown in Fig. 5 and Fig 6, respectively.
However, the largest ambiguity in the period in any selected model is less than 6 days, and the mean period ambiguity over all the 358 discrete models for rat 1 is 0.5 days, and over all the 487 discrete models for rat 2 is 0.4 days.
Popular models for Rat Rods include: Mid-century Chevrolet pick-up trucks.
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We first investigated the Ensembl and RefSeq models for rats.
The study has developed a homology model for rat 5-LOX and recognized the key residues at the binding site.
The phase for the most likely model for rat 1 was 4 days, and that for rat 2 was 7 days.
The TK model presented here was also compared with results from a published model for rat hepatocytes, in order to assess the inter-species differences and the feasibility of direct, cross-species extrapolation.
The PBPK model for rats predicts that the terminal elimination t1/2 is constant at exposures of ≤0.1 μg/kg and increases to approximately 10 days as dose increases from 0.1 to approximately 100 μg/kg in the fixed elimination model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com