As some of these authors have previously shown3, the persevering mice provide a model for persistent drug use despite negative consequences, and parallel the subset of human drug users whose drug use becomes compulsive.
Predictors that were no part of the CCA model entered the MI-5 model for persistent shoulder disability (e.g. duration of complaints, somatisation, external locus of control and age) were included in the MI-5 model.
In experimentally injured rat livers induced by ligature of the common bile duct, a model for persistent fibrogenesis and cirrhosis, administration of the adenoviral vector abrogates TGF-β-enhanced production of collagen and α-smooth muscle actin.
The results concerning the effects of diabetes and severe obesity did not change when ASA score and BMI were added to the adjusted models: OR for persistent pain in patients with previously diagnosed diabetes was 20 (CI: 3 132) and OR for a painful joint in severely obese patients was 4 (CI: 1.3 14).
The candidate model set for each guild included models of persistent forest, disturbed forest, post-disturbance forest, post-disturbance non-forest, disturbed forest and post-disturbance non-forest, and disturbed forest with post-disturbance forest.
The cysteine biosynthetic pathway is up-regulated in models of persistent M. tuberculosis infections and provides potential targets for novel anti-mycobacterial agents, directed specifically toward the pathogen in its persistent phase.
ApcMin mice with heterozygous disruption of Pten develop invasive carcinomas that are large, making this a good animal model for studying persistent activation of the phosphatidylinositol 3-kinase/Akt pathway in colorectal cancer [41].
The local injection of formalin into the hind paw of rodents represents a model for inducing persistent inflammatory pain, which generates a nociceptive biphasic response, oedema, and inflammation [ 35].
Different prediction models for diagnosis of (persistent) erosive disease have been described by means of different ACPA assays [ 22, 23].
Verner et al. have reported an error in their article "Physiologically Based Pharmacokinetic Modeling of Persistent Organic Pollutants for Lifetime Exposure Assessment: A New Tool in Breast Cancer Epidemiologic Studies" [Environ Health Perspect 116:886–892008008)].
