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The pharmacokinetic models developed differ substantially from adult pharmacokinetic (PK) models which can have considerable impact on the dosimetric models for pediatric patients.
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United Hospital of New Jersey recognized him with a special title, given only to him: "Role Model for Pediatric Residents".
This paper presents a management model for pediatric somatization based on principles distilled from the available pediatric and adult literature.
We propose that they might serve as a model for pediatric heart valve reconstruction and replacement valve design.
model for pediatric overweight or obesity involves the following health care professionals: pediatricians, endocrinologists, psychologists, dieticians, and exercise physiologists.
The IMPACT study provides a model for pediatric research on adverse event management using state-of-the art methods.
The litter size and early sexual maturity are factors favoring the minipig as model for pediatric drug safety studies.
This finding is in line with the advanced state of human postnatal organ development at comparative age categories and further supports the minipig as model for pediatric drug safety studies.
POTS II will also address the question of whether all patients need therapist-assisted exposure or if some patients improve with instructions alone, as a step toward developing a stages of treatment model for pediatric OCD.
The selection of an appropriate structural model for pediatric PK studies is similar to the approach used in adult PK studies, albeit with the caveat that simpler, compartmental models are often favored for pediatric studies due to the limited number of blood samples that can be obtained from small children.
Earlier this year, the FDA's Pharmaceutical Science and Clinical Pharmacology Advisory Committee voted in support of extending the use PBPK modeling for pediatric drug development although several members of the committee emphasized the need for more data and prospective evaluation and validation of the models with observed data (http://www.fda.gov).
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