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In general, miniature pigs become obese when fed ad libitum and are therefore employed as models for obesity and metabolic syndrome.
While rodent models for obesity and diabetes are well established [121], [122], here we propose Thoroughbred as a novel in vivo large animal model that may contribute to further insights into the complex molecular interactions that serve to protect against obesity and related pathological phenotypes that are influenced by exercise.
All these approaches have been used in humans and rodent models for obesity and diabetes, and thus provide a powerful link between pre-clinical investigations of animal models and clinical studies of patients.
We addressed the potential role of obesity as a confounder by controlling our final multivariate models for obesity status, and we assessed obesity as an effect modifier by running these final models separately for obese and nonobese subjects.
To support community-created causal models for obesity [ 23] and initiatives by the DRPHC, the need for locally generated surveillance data on health outcomes and behavioral factors related to obesity was identified as a priority.
There is a vast amount of research on the genetic and environmental interactions associated with complex polygenic physiological traits in pigs, making them relevant models for obesity, female health, cardiovascular disease, nutritional and communicable disease studies [ 13].
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Two must-reads: Gary Taubes's fantastic Op-Ed questioning the conventional wisdom on salt consumption, and this paper detailing how existing alcohol control policies could be used as a model for obesity prevention.
In this paper, we propose a fractional order epidemic model for obesity contagion.
Voluntary wheel running reduces the hepatic TG content in Otsuka Long-Evans Tokushima Fatty rats, a rodent model for obesity and type 2 diabetes [8].
However, marked differences in metabolism and adipose tissue biology between rodents and humans have been recognized and, thus, the pig is emerging as a more appropriate biomedical model for obesity in humans because of its biological similarities with humans [3].
What is the appropriate medical model for obesity management?
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