Exact(1)
It has been argued that due to these differences between murine and human CLCA orthologs, the value of mouse models for mucus cell metaplasia in translational medicine is questionable.
Similar(59)
An approach including an ovalbumin challenge as the preferred model for studying mucus cell differentiation and mucus cell metaplasia in mice (Long et al. 2006; Nakanishi et al. 2001; Robichaud et al. 2005; Zhang and He 2010) may become of special interest in this issue.
Fluorescently-labeled chitosan-coated PLGA nanoparticles (NP, ∼168 nm) were used as a model drug delivery system to evaluate the suitability of this in vitro model for studying mucus permeation and cell uptake.
Consumed food provides additional stimulation necessary for mucus secretion.
And in the famous "Humpty Dance" video, Humpty Hump's overly large nose has a whale like capacity for mucus.
After the clearance of mucus was measured the endotracheal tube was removed for mucus collection (iii).
After the clearance of mucus was measured the endotracheal tube was removed for mucus collection (i).
As all the spontaneous mouse colitis models had mucus that was penetrable to bacteria, it can be expected that some patients with UC might also have mucus defects making their mucus less protective.
A previous study identified mCLCA5 as being sufficient to induce mucus production and responsible for mucus cell metaplasia (Patel et al. 2009).
If the mucus coating the epithelium is more abundant in guinea pigs, this is relevant in relation to the widespread use of guinea pigs as models for intestinal Listeria infections [ 26, 27], since the integrity and thickness of the intestinal mucus layer is known to affect the susceptibility to intestinal infection [ 28- 30].
Models for mucociliary clearance call for cilia to extend through the airway surface fluid to contact the mucus in order to generate a propulsive force [15], [17], [39], [40].
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