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The aims of this study were to develop thyroid models for mouse, rat and man, and to compare microdosimetric properties between the models.
The S value was determined for the cell nuclei in species-specific thyroid follicle models for mouse, rat and man for different spatial distributions of radioiodine.
However, in the presented study, the influence of size of follicle and cell nucleus was also studied, and specific models for mouse and rat were defined.
The aims of this study were to develop thyroid models for mouse, rat and man, and to perform Monte Carlo simulations for 211At to study the effect of geometry and biodistribution on microdosimetric parameters for the three species.
Despite these limitations, the models presented here represent a significant progress in developing biophysically detailed mathematical models for mouse SAN cells and form a basis for further development with the advent of new experimental data.
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The model for mouse SMG infection was previously described in detail [39].
To our best knowledge, such experimental data necessary for developing a well-validated Markovian chain model for mouse SAN ion channels are not yet unavailable.
With WEEDER, we use its pre-computed background model for mouse, which contains the frequencies of all 8mers in regions 1000 bp upstream of genes.
In the structural model for mouse Pgp, the catalytic glutamates that likely activate the waters used in hydrolysis of ATP are separated by >30 Å, indicative of a complete disengagement of the two NBDs.
A rejection of a peripatric model for mouse lemurs is also similar to a recent study on mantellid frogs based on range overlap analysis, where the authors found that range size differences among sister species increased with evolutionary age [ 67].
In this paper, we presented data only from mouse animal models, for the mouse was the main model for common human diseases.
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