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Domestic pigs share similarities with humans and represent an excellent animal model for immunological studies.
Our investigation illustrates some of the advantages of integrating experimentation with modeling for immunological studies.
Zebrafish has been recently recognized as a valuable model for immunological studies [48] since adult zebrafish posses an adaptive and innate immune system similar to mammals [49] [53].
Long-Evans rats may be an appropriate model for immunological studies such as exploring the relationships between leukocyte migration responsiveness, chemokine activity, and uterine activation.
The presence of these well-defined tumour-specific antigens renders MSI-H tumours as a unique model entity for immunological studies.
A recent study reporting the lack of analogous gene array variations between human disease samples and mouse models of three major inflammatory conditions––sepsis, burns and trauma has raised concerns regarding the reliability of mouse models in general for immunological research in defined disease models [ 102].
Although mice constitute the most convenient and versatile model for mechanistic immunological research (plethora of genetically engineered strains and immunological reagents), the tiny size of the murine oral cavity has presented technical challenges for ligature placement.
Although xenograft models carry limitations for immunological treatment manoeuvers as they do not completely represent the immunological in vivo complexity of interactions between host, tumour, and treatment, a comparative assessment of the antitumour activity of various constructs in our mouse model may help to choose the most promising constructs for clinical translation.
A relative of T. trichiura that infects mice (T. muris) is a useful laboratory model for study of whipworms and used as a model gastrointestinal nematode for immunological studies (Foth et al. 2014).
Currently there are no animal models for investigating the immunological impact of co-infection.
Since variables reflecting severity of illness (WHO stage, weight-for-height z-score, CD4percentt and absolute count and log viral load) were highly correlated with one another, only the single most predictive variable, i.e. weight-for-height z-score, was included in the multivariate models for virological and immunological outcome.
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