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However, mouse gut community individuality was low relative to other systems and we predict use of inbred laboratory mice as models for gut microbiota-related characteristics of the host will underestimate the importance of such effects in humans.
The pioneering studies cited above on new animal models for gut microbiota research have greatly demonstrated their potential.
The strengths and limitations of mice as models for gut microbiota research are clear, but are there better alternatives for the research community to develop or consider?
The reaction data set was then used to reconstruct two genome scale metabolic models for gut microorganisms available in the IMG database Bifidobacterium adolescentis L2-32, which produces acetate during fermentation, and Faecalibacterium prausnitzii A2-165, whiconsumesmes acetate and produces butyrate.
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Accordingly, using established intestinal models for human gut development [7] [9], we have systematically examined the interaction of colonizing bacteria with the developing human gut.
Non-human primates are also suitable models for human gut microbiota research, with the obvious advantage of close evolutionary relatedness to humans.
To overcome these limitations, we coupled the capability of micro-PET to provide FDG time activity curves (TACs) in virtually all organs with the formulation of a novel compartmental model (see Figure 1) for the hepatic system using the following three descriptors of tracer kinetics in the liver: Figure 1 Compartmental model for the gut and liver.
Finally, we discuss the external factors that influence the capability of mouse models to recapitulate the gut microbiota shifts associated with human diseases, and investigate which alternative model systems exist for gut microbiota research.
The high temporal variation observed in the gut microbiota of inbred laboratory mice has implications for their use as experimental models for the human gut microbiota.
There is an urgent need for novel approaches toward the construction of gut ecosystem-wide association networks to develop global models of gut ecosystem dynamics.
Caco-2 cell line is good model for the gut-blood barrier, while MDCK cell line is considered a good model for the blood brain barrier.
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