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In further evaluating the potential value of spectra generated from tumour tissue for classifying various clinic-pathological characteristics of disease, we observed low ROC errors with the kNN predictive models for differentiation (0.171) and disease recurrence (0.105).
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Pluripotent stem cells are an efficient model for differentiation and have been directed towards both white adipogenic and brown adipogenic lineages.
The influence of laminin-111 (Lm111) and its integrin and dystroglycan (DG) receptors on epiblast in embryoid bodies (EBs), a model for differentiation of the embryonic plate, was further investigated.
A typical model for differentiation adopts bistable dynamics in which transitions between states are driven by noise (e.g., [ 22]).
We report on the establishment of a model for differentiation induction in sarcomas, using the clonal rhabdomyosarcoma cell line BA-HAN-1C.
A well-known in vitro model for differentiation studies derived from rat pheochromocytoma, the PC12 cell line, is used to investigate the potencies of polyphenols on neurite outgrowth.
The current model for differentiation supports a co-ordinated process whereby inhibitors of differentiation are down-regulated prior to up-regulation of factors necessary for myelin gene transcription (Li et al., 2009).
Ocular lens is a unique model for differentiation studies because the lens is composed of a single type of cell that reaches different stages of differentiation, either as lens fibers or lens epithelium depending on its spatial localization in the lens (Lovicu and McAvoy 2005).
Moreover, due to the potent adipogenic differentiation capacity, porcine DFAT cells were used as preadipocytes models for adipogenic differentiation [ 26].
The multiple co-culture systems established in this study provide new methods for directing committed differentiation of stem cells as well as new in vitro models for studying differentiation mechanism of stem cells determined by a tissue-specific niche.
Differentiation of myoblasts to myotubes is one of the best cell culture models for vertebrate differentiation.
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