While the FCTC may not be the appropriate model for diet and obesity, the paper makes a special case for the development of binding international standards in select areas of diet and nutrition.
We investigated the effects of 7 diets from a single manufacturer containing 11 58 en% protein (casein), 0 81 en% carbohydrates (CHO; sucrose, maltrodextrin-10 and corn starch), and 8 42 en% fat (triheptanoin, olive oil or cocoa butter) in C57BL/6 J mice, a good model for diet-induced obesity and fatty liver.
Results presented herein demonstrate that compared to a traditional HFD model, the CAF diet provides a robust model for diet-induced human obesity, which models Metabolic Syndrome-related mitochondrial dysfunction in serum, muscle, and adipose, along with pro-inflammatory metabolite alterations.
MTCRII may thus provide the basis for an intermediate risk assessment model for diet- or lifestyle-related genotoxic/nongenotoxic chemical combinations, relevant to colonic health.
Our results suggest that BioF1B Golden Syrian hamsters are a potential model for diet-induced metabolic syndrome with associated non-alcoholic fatty liver disease.
To determine how successful our approach was in identifying plausible novel candidates, we compared differentially expressed genes from our mouse model for diet-induced diabetes with previously reported single nucleotide polymorphisms (SNPs) associated with type 2 diabetes in humans.
In the present study we therefore studied myocardial function and perfusion under baseline and pharmacological-induced hyperaemic conditions in a rat model for diet-induced glucose intolerance using contrast echocardiography.
Although zebrafish larvae have been used in genetic and chemical screening experiments to identify novel genes involved in the regulation of energy homeostasis and potential therapeutic targets to treat obesity [ 13, 23], it remains unclear whether zebrafish can be used as a model for diet-induced obesity (DIO), similar to that observed in mammals.
Daily Growth Coefficient (DGC) was studied using a model accounting for diet as a fixed effect and tank, sire, dam, sire*diet and dam*diet as random effects, using SAS-GLM.
