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Franco is also collaborating with a researcher who came to his lab seeking help in refining his mouse models for diabetes.
Taken together, compound 51 shows high potential warranting further studies in models for diabetes and related metabolic disorders and may be in use as a chemical tool for the understanding of PPAR biology.
Resource allocation models for diabetes or its prevention have been undertaken previously [ 23, 25, 26].
Several models for diabetes care have been developed and evaluated [ 9].
We identified 46 studies that derived risk prediction models for diabetes.
The current study used the GK and dexamethasone-treated rats as models for diabetes and hypercortisolemia, respectively.
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It has been shown that administration of insulin detemir to Zucker diabetic fatty rats (an animal model for diabetes) results in smaller increases in fat mass than either insulin glargine or NPH insulin.
The modeling capabilities of this tool were used to model the Michigan model for diabetes.
Our first transgenic rat line generated with this method represents an inducible model for diabetes mellitus.
GIMAP5 gene mutations have been shown to contribute to T1D in the rat model for diabetes [62], [63].
These data support the development of renal damage in the chronic rat model for diabetes mellitus, already after 5 weeks of low dose treatment with DOX.
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