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Animal models for asthma have been used for over 100 years and considered as an ideal vehicle for testing and identifying the mechanisms behind the asthmatic phenotype.
What are the most appropriate animal models for asthma, especially when studying low-molecular-weight agents?
Existing predictive models for asthma development in children have several limitations.
Substantial effort has been invested in predictive models for asthma development in children.
Existing predictive models for asthma development in children have inadequate accuracy.
A summary of the predictive models for asthma development in children is given in Table 1.
Similar(28)
The let-7 family miRNAs have been shown to post-transcriptionally regulate the translation of the helminth-controlling cytokine, IL-13, in a murine model for asthma and we hypothesize possible interactions between these host- and parasite-derived miRNAs and their immunomodulating roles.
Inclusion of variables representing presence of allergen-specific IgE antibodies or of log10IgE in the multiple logistic regression model for asthma also had no major impact on our primary finding of an inverse association with CagA+ H. pylori strains.
This study aimed to identify key TLRs involved in antigen induced pulmonary inflammation (AIPI), a rat model for asthma, and to explore the role of TLRs in the disease development.
Several studies previously developed a prediction model for asthma [ 5- 12].
We have identified several limitations and open problems in predictive modeling for asthma development in children.
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