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While these models faithfully recapitulate the histopathological features of human gliomas, comparative genomic analyses are increasingly being utilized to comprehensively assess their fidelity to recently identified molecular subtypes of these tumors.
These mouse models faithfully recapitulate the pathology and disease course seen in the human patients.
PDX models faithfully recapitulate the intra-tumor heterogeneity and response to chemotherapy [ 53].
YAC128 and other HD mouse models faithfully recapitulate the pattern of molecular changes observed in human postmortem caudate tissue from individuals with HD using high-throughput mRNA expression profiling (Hodges et al., 2006; Kuhn et al., 2007).
However, with the exception of rabbits and NHP, no other animal models faithfully recapitulate the spectrum of clinicopathological features found in Mtb-infected humans, from progressive (primary) TB to LTBI and reactivation (secondary) TB [ 10, 11].
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Although several mouse models have emerged as useful platforms for mechanistic and therapeutic studies of alterations in signaling pathways found in human MM (e.g., IL-6, Abl, and Myc), none of the models faithfully recapitulates all features of human MM.
This indicates that the AC/AE model faithfully recapitulates early heart development (Fig. S3).
This OSA animal model faithfully recapitulates some of the most important features of the human malignancy, such as lung metastatization.
Thus, the model faithfully recapitulates the human condition with deregulated MYCN as the initiating event biologically and genetically [ 25- 27].
The new model faithfully recapitulated many of the findings that have been made in other model systems, and showed a gene expression pattern that mirrors the signature found in t(8 21) blast samples expressing AML1-ETO.
We demonstrate that our DCIS model faithfully recapitulates key structures and functions of human mammary DCIS and can be employed to study the mechanisms involved in the invasive progression of DCIS.
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