Sentence examples for models expressing both from inspiring English sources

The variability in plaque load between mice of the same age is relatively low in homozygous ARTE10 mice but comparable to other models expressing both APP and PS1 at an equivalent age.

Furthermore, cetuximab has antitumour activity in NSCLC models expressing both wild-type and mutated EGFR (Steiner et al, 2007).

There is also evidence that mouse models expressing both mutant amyloid precursor protein or Presenilin 1 have some tau present along the vasculature [ 13, 75], but this was speculated to be a consequence of Aß deposition rather than a pathophysiological function of tau.

Thus, models expressing both repeat RNA and DPR proteins and constant comparison with pathological analysis of patient samples are needed to elucidate the cause of neurodegeneration in C9orf72 repeat expansion carriers, and how this can lead to either FTLD or MND.

By using Western blotting we found that HEK293 was a natural model expressing both EPR-1 and Survivin simultaneously.

The cellular model expressing both GFP-CL1 and α-synuclein may be a useful tool to screen compounds protecting neurons from α-synuclein-mediated proteasome dysfunction.

Therefore, we crossbred two genetically modified mouse strains to achieve a model expressing both atherosclerosis and characteristics of type 2 diabetes (63).

Neuronal loss has, however, been reported in a rat model expressing both PS1 and APPsw (Cohen et al., 2013), indicating that some animal models might be more suitable at recapitulating the disease.

We have previously described a transgenic (Tg) mouse model expressing both mouse c-FlipL and enhanced green fluorescent protein (EGFP) in the cardiac muscle under transcriptional control of the 400 bp trStra8 promoter in a unique bicistronic transcript.

In order to test the possible influence of 51A synthesis on SORL1 pre-mRNA splicing, we measured by real-time RT-PCR the expression of 51A RNA and SORL1 splicing variants in different cell lines in order to identify an in vitro cellular model expressing both 51A RNA and SORL1 variants.

7– 12 In this study, we found that the cells used in our model expressed both HGF and MET (Fig. 3), and that treatment with the MET inhibitor PHA665752 or anti-HGF neutralizing antibody significantly suppressed the in vitro migration and invasion activities of G3H cells using CM of G3H as a chemoattractant (Fig. 4).