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Diesels have grown up, as automakers including Audi, BMW, Mercedes and Volkswagen have been proving with new models engineered to take advantage of new ultra-low-sulfur fuel.

Murine transgenic models engineered to recapitulate human breast cancer provide an excellent and straightforward approach to dissect the molecular mechanisms governing the onset and progression of this disease.

Reprogrammable mouse models engineered to conditionally express Oct-4, Klf-4, Sox-2 and c-Myc (OKSM) have been instrumental in dissecting molecular events underpinning the generation of induced pluripotent stem cells.

In this study, we characterized the cell cycle parameters change in 3D by using pancreatic MCTS models engineered to express cell cycle fluorescent reporters.

These features are similar to several mouse models engineered to perturb the WNT pathway (Batlle et al, 2002; Sansom et al, 2004; Madison et al, 2005; Finch et al, 2009).

The intestinal epithelia of these mice showed several similarities to mouse models engineered to perturb the WNT pathway (Batlle et al, 2002; Sansom et al, 2004; Madison et al, 2005; Finch et al, 2009).

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Here, we have combined vascular magnetic resonance imaging (MRI) and optical imaging to understand the relationship between hypoxia and vascularization in a human prostate cancer model engineered to express enhanced green fluorescent protein (EGFP) under hypoxia.

The efficacy of R-LM113 was assessed in a platelet-derived growth factor (PDGF -induced infiltrative glioma model engineered to exPDGF -inducedd transplanted infiltratively in adult NOD/SCID mice.

The homeostatic T cell regulation of tumours can be tested in a tri-transgenic mice model engineered to express potent oncogenes in a doxycycline-dependent manner.

The protective effect of RTL therapy on the iatrogenic effect of primary tumour resection could be tested in a tri-transgenic mouse model engineered to express potent oncogenes in a doxycycline-dependent mammary-specific manner [ 32].

Both viral models were engineered to express a Green Fluorescent Protein (GFP) which facilitates microscopic inspection and analyses of infection.

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