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Dispute transformation and resolution in these models display two interdependent but closely interconnected dimensions.
Pharmacophore models display two main advantages: reduced computational times associated to the simplified pharmacophoric representations and a large diversity of potential hits with scaffolds and functional groups distinct to the original ligands [31, 32].
The three models display two stem loops and one small stem (stem 3).
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Tumours from the three tumour models displayed three distinctive vascular morphologies, which were best assessed on post-USPIO gradient-echo images.
The above-identified bacterial family which overlaps with the Pfam DUF3893 model displayed two unique, absolutely conserved residues: an arginine and a glutamate (see Figure 2A).
In the case that the same regulation is predicted by the network transfer of both model organisms, we store and display two in silicio evidences for this regulation and refer to the two experimental validated regulations in the model organisms.
Our model displays two features that make it relevant as a pre-clinical paradigm: i) our protocol involves a therapeutic rather than prophylactic setting [25]; ii) alike most spontaneous human tumors, B16.F10 cells do not express MHC II and display only low levels of MHC I molecules [26].
The two models display the same overall tendencies although identical results are not possible to obtain, due to differences in the basic assumptions usually made for upper and lower bound analysis of connections.
However, the two models display distinct synaptic and behavioral alterations and it would thus be interesting in future studies to examine the consequences of mutations preventing the expression of both proteins.
The majority of the cell population of the primary tumor of both the MARY-X and canine models display a strong membrane-positioned E-cadherin (green) expressing cells with no expression of sLex (Figure 2A & 2B).
Females of all three models display higher Aβ load burden and plaque quantity as compare to the male counterparts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com