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However, the models detected significant cohort and period effects for both cervical and breast cancer, where clear trends were observed.
Similarly, recent studies on miRNA-122 knock-out models detected significant, persistent decreases in serum triglycerides [ 30].
And yet, the APC models detected significant effects, suggesting the method is adequate for detecting important factors in the complex trends of these three diseases.
These models detected significant migration from R. palmatus to R. grayanus (pEB to gYK, pYK to gYK, and pEB to gTN) and from R. grayanus to R. palmatus (gYK to pYK, and gTN to pEB).
Of the remaining 10 (Supplementary Fig. and Supplementary Table), mixture models detected significant effects for 7, nearest neighbor 4 and minimum 4. Of the seven mixture-model identifications, three were also detected by nearest neighbor, two also by minimum imputation and two were unique identifications.
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By analyzing a real example for pain genetics, the new model detects significant haplotypes composed of three SNPs within the kappa-opioid receptor, which may play an important role in affecting pain sensitivity to heat.
Consistent with this widely accepted R-Avr interaction model, we detected significant up-regulation of transcripts for MAPK, CIPK, SNF1-related PK regulatory subunit, and other PKs in P. monticola resistant seedlings following rust infection.
Regarding the interaction between sex and the tested variable, only one out of six models detected a significant interaction (WHtR and microalbuminuria).
Survival plots for females are shown in Fig. 4. A Cox proportional hazard model was used and detected significant differences among populations for each temperature (with the only exception for females at 12°C, table 2).
All models properly described the response and detected significant differences between dose levels.
Bivariate and multivariate linear regressions were run, but a lack of data points reduced the power of these models to detect significant associations, especially non-linear associations and interaction terms both of which are likely given the complex nature of potential causal pathways between the variables and MMR, therefore these results are not included.
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