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All models could replicate wild type maps and produce qualitatively correct double maps seen in Isl2-EphA3 ki/ki mice.
Moreover, the authors did not demonstrate the human origin of the bone cells and matrix, nor did they show that their models could replicate the osteolytic pattern of bone metastasis.
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Similarly, the duo found their model could replicate Facebook's trajectory, which according to the Google search data appears to have plateaued in recent years and has fallen slightly since 2012.
But demand for daily deals began to stagnate and then retreat, forcing LivingSocial to hunt for other business models that could replicate its early success.
We next looked for cell line models that could replicate the phenotype that we observed in the clinical samples.
The team's first step in this quest was to create a mouse model that could replicate a human meditator's brain.
We were pretty sure the show itself would rock the house, but our ultimate dream was to create a model that others could replicate.
Using this approach, we specified which facets of shedding certain models could not replicate.
Although animal models could never replicate a phenotype as complex as alcoholism, they can mimic certain facets of the trait, which then can be associated with specific expression signatures using gene expression microarrays.
In order to validate that our findings were not due to chance or linkage disequilibrium (LD) with a nearby functional variant, we used a knockout mouse model to determine if we could replicate our results in an experimental setting.
"Ideally, from his perspective, he could replicate the Chinese model by normalizing foreign relations, from the U.S. down, on the basis of a nuclear deterrent," Mr. Delury said.
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