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Traditional breast cancer (BrCa) bone metastasis models contain many limitations with regards to controllability, reproducibility and flexibility of design.
Although modern numerical models contain many degrees of freedom, only a few degrees of freedom are typically measured using conventional instrumentation such as strain gauges and extensometers.
2. Biochemical reaction models contain many parameters whose numbers dramatically increase with model size and detail.
It was observed that data-optimized models contain many fewer interactions than the original network graph, suggesting the presence of many false-positive interactions at least for the HepG2 cells under study.
Although our simple models contain many plausible relations that have some precedent in previous epidemiological observations, they were developed and calibrated in the absence of some important numerical data (e.g., data stratified by age and gender).
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Moreover, traditional CAD models containing many small (and possibly trimmed) patches are not directly usable for IgA.
A black-box approach can be used more universally, but results in models containing many parameters that cannot easily be interpreted.
A modular model specification allows for straightforward creation of large-scale models containing many compartments and reactions.
However, MaxiMin provides better results in case one of the two models contains many more nodes than the other.
The top cluster of 2000 ROSETTA models contained many more models, 268, than the next most populated cluster (81) indicative of likely success.
The model contains many assumptions and simplifications, Bobashev says.
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