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In multivariable models constrained to require that diseases resulting in no burden of illness receive no NIH funding (equivalent to requiring an intercept of zero-zero in the regression line, expressed in the dashed line of Figure 2), expected funding amounts were generally similar to those found with the unconstrained multivariable model (Table 3; Figure 3).

Then, we compared the classifications to those obtained by LCA models constrained to have baseline class-specific health indicator probabilities.

The results of internal consistency analysis of models constrained to three factors are shown in Table  6.

Taken together, these observations support the idea that GRNs carry a strong signature of BQS and that random models constrained to be similar to GRNs will inherit, at least in part, many features of BQS.

When we compared T1 and T2 profiles with those obtained with T1 and T2 models constrained to have baseline conditional health indicator probabilities, the concordance in how individuals are grouped reaches 90% at T1, and 88% at T2.

Formal statistical testing for stabilizing selection (a peak in fitness at intermediate values of m6), showed that models constrained to have their maxima at either the minimum (t89 = 5.17, p < 0.001) or maximum (t89 = -4.54, p < 0.001) of the phenotypic distribution produced significantly worse fits than the unconstrained model.

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Similar(51)

The experimental set-up consists of a simple bluff body (Davis model) constrained to oscillate with a single degree of freedom of pure yawing motion.

Connors and Rostoker (2015) discuss that AFM applied on a meridian with field-aligned currents in the model constrained to be very distant is similar to finding equivalent currents.

Therefore, it is not understood, a priori, to what extent does a model constrained to pairwise correlations in the mass spec data captures known interactions.

In contrast, a random model constrained to have the same connectance as the empirical data would reproduce a fraction C (24%) of the links and 1−2C−C2 (63.4%) of the connection matrix entries correctly.

This result was supported partially by testing the model constrained to a single latent factor.

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