Exact(1)
On the other hand, cohort effects remained (see Table 2, Step 7) even after all other factors (including remoteness) were controlled for, suggesting that other (non-assessed) cohort related factors were also associated with impaired physical HRQoL; however, in both of these models cohort accounted for under one percent of the explained variation (see Additional file 1: Table S1).
Similar(59)
Terms for cohort effects were also estimated in the models; cohorts were defined by age group at baseline (65 69, 70 74, 75 79, 80 84, or 85+).
bEffects were assessed by comparing the age period cohort model with the age-cohort model (period curvature effect) and the age period cohort model with the age-period model (cohort curvature effect).
The model cohort will start at the age of 6 years where mixed dentition is emerging.
The total number of low-expressing miRNAs for each tumor in the model cohort was determined.
In both the age-period-cohort model and the age-cohort model, cohort curvature effects were not statistically significant (p = 0.46 and p = 0.08, respectively).
Baseline characteristics for the model cohort, treatment effects and resource utilisation were all informed by this trial.
Our discovery cohort was assayed using a TaqMan array, the model cohort was assayed using a Fluidigm array, and our validation cohort was examined using an Illumina array.
The 4 miRNAs profiled are highly significantly associated with pCR in the model cohort (Ptrend =.008), the validation cohort (Ptrend =.025), and the combined cohort (Ptrend = 4.6 × 10−4).
To estimate the factors associated with mortality we split the population into two randomized cohorts: model cohort (including 80%) and validation cohort (20%).
As a model cohort we used a well characterized patient cohort which has undergone surgery for lumbar spinal spinal stenosis in a prospective study design.
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