Theoretical modeling cannot replace experiments, but we believe that our model can considerably accelerate optimization of oligonucleotides for gene therapy by predicting their pairing dynamics with the target dsDNA.
We show that a small parameter window of chaotic behaviors in the deterministic model can considerably be widened by noise.
It has been found that the predictions between the models can vary considerably, particularly for the turbulent kinetic energy, its dissipation rate, and the eddy viscosity.
While operator data has been shown to predict infectious disease spread, e.g. for cholera [20], it is likely that these models can be considerably improved by accounting for differential socio-economic composition of travelers.
Implicit water models can be considerably faster to compute, because the implicit solvent contributes no or few degrees of freedom to the simulation.
Obviously, the inclusion of models with low restrictivity and low EF into a model collection can considerably impair the predictive power of the entire system.
The simulation results indicate that blade vibration and deformation have significant effects on the aerodynamic loads, and the dynamic stall can cause more violent fluctuation for the blade aerodynamic loads compared with the steady aerodynamic model, which can considerably affect the blade fatigue load spectrum analysis and the fatigue life design.
The usual practice of approximately representing the duct flow with the midspan profile results in a slight overestimation of the average Mach number in the two-dimensional acoustic models, and thus can considerably affect the accuracy of the impedance eduction.
The performance of our reduced models suggests that we can considerably simplify our original models of 18 variables.
The term "how-actually-enough" captures the idea that the requisite "accuracy" of a mechanistic model can vary considerably from one pragmatic context to another (Weisberg 2013).A false how possibly model is merely a how possibly model; just-so-stories are merely how possibly models (Dray 1957; Brandon 1985).
