In the present study we tried to decrease the levels of NO in our GTN headache model by administering pure oxygen in a dose, 7 l/min which has been shown to be effective in the treatment of cluster headache in a double-blind trial [8, 9] and in clinical practice [8, 10].
We next explored whether GM-CSF was critical also for joint pain development in this OA-like model by administering a neutralizing mAb to GM-CSF prophylactically.
To achieve an increase in epithelial permeability we modified the model by administering LPS continuously [ 21] instead of increasing a bolus dose.
Here, we have examined the function of TIM-2 in the development of collagen-induced arthritis (CIA), which is a Th1-mediated autoimmune disease model, by administering a newly generated anti-TIM-2 monoclonal antibodies (mAbs).
We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal anti-inflammatory drugs (NSAIDs) with differing selectivity profiles: robenacoxib (COX-2 selective) and ketoprofen (COX-1 selective).
LPS injury was performed as a two-hit model by administering a single bolus of 1 mg/kg body weight intraperitoneally 24 hours prior to the experiment, followed by a constant intravenous infusion of LPS (1 mg/kg/hr) during the 6-hour experimental period.
Type-1 diabetes is an autoimmune disease that destroys insulin-producing pancreatic β-cells, which we modeled by administering the β-cell toxin STZ (Sigma S0130) to mice at 8 weeks of age fed a ND (ND+STZ; Arora et al., 2009; Gilbert et al., 2011).
We chose to estimate our mapping model by administering our questionnaire to patients undergoing coronary artery bypass grafting (CABG), for two reasons: 1) clinical trials investigating surgical interventions frequently use the VAS when assessing outcomes; and 2) patients undergoing CABG vary widely in the severity of their health conditions pre- and postoperatively.
This model may be improved, for example, by administering antimicrobial drugs or creating transgenic mice.
Secondly, we constructed an artificial short-term model of hypoxemia by administering a hypoxic gas mixture.
