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However, no zebrafish models bearing human premature senescence currently exist.
This result was further confirmed by comparisons in nude mice models bearing human HCC with different metastatic potentials [ 12].
Further studies are needed to confirm this schedule-dependent effect of sorafenib in animal models bearing human hepatocellular carcinoma xenografts and in clinical studies.
CBF inhibits cortactin expression and nuclear translocation in colon cancer cells in vitro and in mouse models bearing human colon tumour in vivo, suggesting it might disrupt actin-regulated cell movement.
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In this study, we used a combined regiment of ACBP-L (from liver) with a lower dosing Cisplatin, which could reach the same anti-tumor efficacy as the higher dosing Cisplatin alone in the xenograft nude mouse model bearing human gastric cancer MGC-803.
In this sense, it is noteworthy that the transgenic models of FALS, bearing human (Dal Canto and Gurney, 1995; Bruijn et al., 1997) or murine (Morrison et al., 1998) mutant SOD1 do not present a significant loss of motor neurons prior to the onset of symptoms, and the time course of neuronal loss occurs at a very fast rate over a period of 10 days (Morrison et al., 1998).
As this combination showed enhanced activity when administered with CA4P in the KAT-4 model (nude mice bearing human anaplastic thyroid cancer xenografts) (Yeung et al, 2007) and as better therapies are needed for these cancers, a clinical trial was indicated.
Some animal models bearing enforced human NPM1-mutant expression showed an expansion of hematopoietic cells and developed myeloproliferation, indicating a pathogenic role of mutant NPM1 protein in myeloid disorders [ 29, 30].
Further investigation using these knockdown fish models and those fish bearing human mutations which yield similar phenotypes to human disease may give clues to the function of FKRP in the glycosylation of α-dystroglycan and the maintaining of normal muscle.
The latter finding could be confirmed in an in vivo cancer model using Balb/c mice bearing human ovarian cancer [51].
Therefore, our mouse model, BALB/c athymic nude mice bearing human epidermoid cancer (A431), dose not seem to be suitable for evaluating the potentials of F-FDG.
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