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Accounting for them in Cox models attenuated the association of breast-feeding with diabetes.
Adding BMI to the models attenuated the TRs and trends, although some associations were still significant.
Including bone mineral density in these models attenuated the risk by less than 4% (data not shown).
The addition of lean mass to the models attenuated the association between BMD and wbPA, which suggests that this association may be partially mediated through lean mass accumulation.
Models 1 and 2 showed that including all variables in the same models attenuated the estimates somewhat, but the overall pattern in the results remained the same.
We also found that age, sex, and functional status all predicted adverse outcomes, and including them in statistical models attenuated the effect of the prognostic score.
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Thus, the lower level of endogenous oxidative stress in these longevity models attenuates the ASK1-signalosome →p38 MAPK activity which favors longevity.
Adjustment for other health-related variables, BMI in particular, led to attenuation of the association (adding BMI to the model attenuated the pooled HR to 1.38, 95% CI 1.19 to 1.60).
Including established risk factors, particularly baseline BMI and BMI2, in the model attenuated the risk associated with HIV infection.
Including HSV-2 infection in the multivariate model attenuated the positive association between HIV and a higher lifetime number of sexual partners.
Adding STI-related covariates to the model attenuated the positive association of HIV infection with age and lifetime number of sexual partners and rendered non-significant the positive association between HIV infection and scarification or prior STI treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com