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The software circumvents the need to prepare and run computationally intensive simulations, by invoking ANN models as surrogate simulators.
Third, the optimization system is set up, which uses the separated particle swarm optimization (SPSO) as search algorithm and combines the Kriging models as surrogate model during optimization.
This paper presents an assessment of the efficiency of the Kriging interpolation models as surrogate models for structural reliability problems involving time-consuming numerical models such as nonlinear finite element analysis structural models.
In this review, we discuss these current advances, specifically new methods for the identification and isolation of pancreatic CSCs, new insights into the metabolic profile of CSCs at the level of mitochondrial respiration, and the utility of genetically engineered mouse models as surrogate systems to both study CSC biology and evaluate CSC-specific targeted therapies in vivo.
However, the use of these cellular models as surrogate stromal cells is presently the best solution.
The steadily increasing acceptance of human primary- or iPSC derived three-dimensional in vitro tissue models as surrogate for clinical responses is another area where only small amounts of RNA are available from spheroid body cultures.
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Therefore, using these habitat models as surrogates for monitoring species occurrence is limited.
The efficiency assessment is performed through a systematic comparison of the accuracy of the failure probability predictions based on the first-order reliability method using the most common first- and second-order polynomial regression models and the Kriging interpolation models as surrogates for the true limit state function.
Part of the problem may be the relevance of animal models as surrogates of human sepsis.
Thus, if one takes into account the biological limitations of genetic mouse models as surrogates for human disorders, the mdx mouse can be employed as an excellent model system to study basic pathophysiological mechanisms of muscular dystrophy [ 73].
Toxicogenomics studies conducted in parallel and comparative systems can demonstrate the biologic relevance of in vitro models as surrogates for in vivo models without the need to address cross-platform (technologic) issues (Boess et al. 2003; Huang et al. 2003).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com