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Further investigations in orthotopic or spontaneous transgenic models of medulloblastoma could provide useful insights in this regard, although the limitations of these models as representative of primary tumours and an intact BBB must also be taken into account.
Comparisons between high-throughput genomic analyses of inducible GEM models of mammary cancer and human breast tumors will provide further molecular validation of specific models as representative of certain subtypes of human breast cancer [ 5, 7, 8].
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A comparison among these models showed that, within fan frequency variations typical of ventilation systems in buildings, the phasor domain model is as representative as the more complex dynamic time domain model in terms of prediction of the dynamic behavior, that is neglected by the basic non transient model.
The simulation-based optimization approach proposed in this paper performs the optimization by genetic algorithm (GA) using PH/PH(n)/C/C DES model as representative of the urban rail transit station walkway.
However, transgenic approaches have successfully reproduced cerebral amyloidosis in mice, and the reproduction of those lesions is one of the main parameters used to endorse an animal model as representative of the human disease.
The latter step often considers each model as representative of an ensemble of similar conformations and some kind of weighted average is performed to pick up the best model (see e. g. [ 6- 9]).
The distmat matrices were used to select the Physcomitrella model as representative for a locus that has the least of all substitutions (minimum distmat distance) to any non- Physcomitrella cluster member.
Thus, applying a more qualitative approach to validate our model as representative of early granuloma formation, we introduced Mtb strains deficient in RD1 (∆RD1) or ESAT-6 (∆ESAT-6) into the experimental tissue.
As a result, integration of relevant omics data with metabolic models as a representative species in the human gut microbiota elucidates the changes in the gut microbiota.
The fuel cell output voltage (FCOV) patterns of the 20 PEM fuel cells were measured, together with the model parameters, as representative patterns.
Moreover, they considered the TNB humic acid model [68] [70] as representative of HS.
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