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The same models as above were used except lines were treated as random effects to obtain estimates of genetic variance.
However, the same models as above arose (see Table 2), this statistic being discarded as an explanatory variable of the ϕ.
We then rebuilt the two full-atom models as above and scored them using ConQuass.
Moderation will be tested using multilevel models (as above) with interaction terms to test moderation.
Pre-specified subgroup analyses were done using models as above, omitting the interaction term.
Potential confounders were entered as covariates using the same models as above.
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Bayesian analyses were performed with MrBayes, version 3.0b4 [ 50], using the GTR + G model, as above.
For the ligand-free states of the c-di-GMP, glycine, and AdoCbl riboswitch aptamers, we performed modeling as above with pseudo-energy constraints from MOHCA-seq proximity maps collected in ligand-free conditions.
Disability variables were modeled as above to calculate multivariate-adjusted PR.
After defining the starting model as above, we assessed, by backward elimination, which confounding factors should remain in the model.
The relative risks were calculated using the exact same model as above, except that the categorical version of the EDI (by quintile) was introduced into the model.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com