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We also demonstrated that miRNA models are prognostic independent of potential confounding by known prognostic factors, such as chemoresponse, tumor location, presence of metastasis at presentation or chemotherapeutic regimen variation (although the latter has not been definitively shown to be prognostic in osteosarcoma to this date).
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The variables introduced in the model were prognostic factors commonly accepted for metastatic breast cancer and parameters previously identified as significantly related to survival in the univariate analysis.
Table 5 provides information on chemotherapy treatments undergone by patients, whether the model was prognostic or predictive, and whether the model was validated using either an independent set of samples or cross validation.
This will complement the available statistical models which are prognostic of acute stroke mortality.
Multiple imputation, to handle missing data, and bootstrapping, to select prognostic models, are increasingly applied in prognostic modeling.
In most applications, Cox proportional hazard models are fitted and prognostic factors are studied for each specific event [ 3].
In the present study, univariate analysis showed that the two models were highly prognostic.
Though many individual prognostic factors for worsening disability have already been identified, studies on prognostic models are sparse [ 11].
Recurrent disease is frequent; however, recurrence patterns are ill-defined and prognostic models are lacking.
Prognostic models are used for mortality predictions and illness severity assessment.
Prognostic models are formulated from patient specific information such as age, pathological subtype, molecular characterisation and tumour staging.
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