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The FE models are manually tuned to reduce the difference between the natural frequencies of the analytical solutions and the natural frequencies of the FE model calculations, respectively.
Gene models are manually checked for errors such as in-frame stops, very short proteins, splits, merges, etc.
A large proportion of models are manually curated to ensure reproducibility of simulation results.
Gene models are manually interpreted from the alignments by annotators using the otterlace annotation interface (32).
20 A large proportion of the kinetic models (45%: 548 out of 1,212 models) are manually curated (fully MIRIAM compliant), a process that includes checking the behavior of the model when instantiated in a simulation.
A large proportion of the kinetic models (45%: 548 out of 1,212 models) are manually curated (fully MIRIAM compliant), a process that includes checking the behavior of the model when instantiated in a simulation.
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Several models for the structure of SLO and the yet unresolved fragments of PDI were generated using modeller [38] and I-TASSER [39] These models were manually refined prior to analysis for a common structural determinant.
Then, each reaction in models was manually checked and corrected, thus making it comparable with the published GSMM model.
The models were manually colored: yellow was choose for the bone, red color lines were painted along the fractured fragments and white color was distributed over the joint surface area (where visible) (Fig. 1) under the supervision of a radiologist.
Intronless gene models were manually checked to verify that a valid signal peptide was predicted.
These models were manually adjusted in order to optimize the geometry of certain regions.
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