Further model advancement, and development of greater confidence in the use of models, is hampered by the lack of thorough evaluation and intercomparisons.
Widespread application of landscape disturbance and succession models is hampered by the difficulty of mapping the initial landscape layers needed for model implementation and by the complexity of calibrating forest landscape models for new geographic regions.
As interpreting pair wise comparison between models is hampered by the large data size for each study, our goal was to use the data in a meta-analysis.
However, the inclusion of tropical wetlands in such models is hampered by a lack of suitable data to validate them.
Treatment with multiple doses of rHIgM12 in animal models is hampered because of a strong anti-human antibody response with subsequent doses that likely inactivates rHIgM12 in circulation.
Yet the investigation of the reliability of statistical models is hampered by methodological problems and by the funders' and researchers' reluctance to invest money and effort in 'mere' replication research.
One study sampled nurses undertaking preregistration education [ 17], so the impact on their work capacity and ability to act as healthy role models was hampered from the beginning of their careers.
Comparison with previously published Swedish osteoporosis models is hampered by the differing objectives of the models; this model estimates the differing costs and health effects for individuals with and without a hip fracture during the first year, while other models are based on clinical trials, where the effects of changing fracture risks are estimated.
Currently, however, the development of multi-scale cell models is hampered by the fact that the enormous experimental progress achieved in making large-scale molecular snapshots of the cell was not flanked by an equally intensive elucidation of the biochemical processes unifying these molecular snapshots to a dynamic picture.
However, the pioneering service provision attempts and advocacy for this model are hampered by a lack of experimental research, and a lack of standardised measures and protocols, which would facilitate a more robust approach to healthcare evaluation and delivery [ 30].
