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JNK activity has also been linked to adverse metabolic outcomes in several critical cellular models and tissues.
The use of murine models and tissues in this study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.
Evidence from experimental models and tissues from DR patients indicate that microglia undergo changes in morphology, location, and numbers in the diabetic retina.
Previous studies examined transcriptional alterations related to heat stress in various mammalian models and tissues [ 10, 11, 15, 17– 19, 21, 22].
Because glucuronidation capacity is immature in early life, the net balance tends to be toward deconjugation in the animal models and tissues studied (Lucier et al. 1977).
In order to elucidate the specific mechanisms by which TCDD and the AHR elicit toxic outcomes, several groups have examined the AHR-mediated transcriptional events in various animal models and tissues following TCDD exposure [ 12, 13, 22– 26].
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Clinical observations and studies in animal models and tissue cultures indicate that Stx2a, the SPATEs Pic and SigA, as well as the pAA-encoded virulence factors, in particular AAF/I, contributed to the high pathogenicity of the outbreak strain5,6,7,8.
We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration.
We analyzed the function of Alx4 during GT formation with a series of genetically modified mouse models and tissue labeling experiments.
There is an accumulating body of data coming from human biopsies, human TTR transgenic mouse models and tissue culture systems, indicating that in the TTR amyloidoses, tissue dysfunction precedes TTR fibril deposition [ 8, 11– 13].
The role of Th17 cells and IL17 cytokines in CD is not completely understood, and data on this issue has been obtained from animal models and tissue sample studies from inflamed mucosa [ 9– 11].
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