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Activation of a so-called mesenchymal program (involving genes such as MMP-2/9 and alphavbeta3 integrins) was found to be dependent on NF- κB activation in OS model, and reversal of EMT was triggered by NF- κB inhibition [ 9– 11].
Over the past decade, many immune tolerance agents have shown promise in the non-obese diabetic mouse model for prevention and reversal of type 1 diabetes but have not been successful in clinical trials among recently diagnosed type 1 patients.
Studies using this animal model have demonstrated protection and reversal of glomerulosclerosis by treatment with Fluvastatin [ 64] and the cyclin-dependent kinase inhibitor CYC202 [ 67] respectively.
Post-synaptic activity of rotigotine was demonstrated in rats via two models: reserpine reversal and stereotypy induction [ 27].
Merrill and McFadden (1999) point out several reversal models and bring up different magnetic field configuration during polarity transitions, which include dipoles as well as higher multipoles.
The decisive elements for the model are the voltage dependencies and reversal potentials of the omega currents.
The model values for the various membrane conductances and reversal potentials were estimated following the procedure outlined in Text S1.
One of the first extensions was to simultaneously model both reversal and duplication events [ 61].
b Histogram of latitudinal difference (degrees) between matching CS10 model and measured convection reversal coordinates.
The need for substantive empirical assumptions arises in settings where there are instances of arithmetical possibilities that are marked out by Simpson's Reversals in urn models and in possible and actual empirical settings.
The negative pick matrix, which models the reversal effect of sentiment-induced mispricing, exhibits the best performance of all considered sentiment strategies (i.e., versions of the pick matrix).
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