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A growth compromised herpes simplex virus type 2 (HSV-2) mutant which is deleted in the PK domain of the large subunit of ribonucleotide reductase (ICP10ΔPK) protects from HSV-2 challenge in the mouse and guinea pig cutaneous and vaginal models and reduces the incidence and frequency of recurrent disease (Vaccine (17) (1999 19511; Vaccine (19 2001 1879879).
The dithiolethione, oltipraz, is a putative cancer chemopreventive agent that induces phase II detoxifying enzymes in preclinical models and reduces aflatoxin adducts in humans living in areas with high dietary levels.
Our most advanced candidate exhibits structural and bnAb binding properties comparable to full-length HA, completely protects mice in lethal heterologous and heterosubtypic challenge models, and reduces fever following sublethal challenge in cynomolgus monkeys.
The Pim inhibitor LGH447 reduces bone disease in MM xenograft models and reduces formation and functionality of OCs.
This description is similar to rule based models, and reduces the complexity drastically compared to a full ODE system [ 12].
In the context of cancer treatment, STS is well-tolerated in animal models and reduces the side effects of various chemotherapy regimens [ 22, 24].
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We report numerical tests that validate the accuracy of the models, and reduce the calculation time.
According to the Commission, the framework will boost recycling and prevent the loss of valuable materials; create jobs, economic growth and new business models; and reduce greenhouse gas emissions.
The purpose is to take advantages of efficient models and reduce the overall computational cost without loss of local precision.
In terms of these computational models and reduced dimensions, mathematical formulations describing physical phenomena within fuel cells are developed.
The focus of the research work being discussed in this article is the systems engineering of PEMFC with the help of both detailed models and reduced order models.
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CEO of Professional Science Editing for Scientists @ prosciediting.com