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The results found using fixed-effects models and pooled logit models were consistent across some dimensions while conflicting across others.
The results found when using prescription medication as the dependent variables paint a very similar picture as our main results, both when using fixed-effects models and pooled logit models in the estimations (see Tables 7 and 8).
HRs were estimated in each country by using Prentice-weighted Cox regression models and pooled by using a random-effects meta-analysis.
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We repeated the 2-stage meta-analysis, estimating study-specific prevalence ratios using log binomial regression models and pooling them to give summary prevalence ratios across the 10 studies.
The pooled positive LR (fixed-effect model) and pooled negative LR (random-effect model) were 4.82 (95 % CI 3.69 6.30) and 0.18 (95 % CI 0.09 0.35), respectively.
In contrast, Neiman et al. [ 17] violated this basic assumption of the clonal turnover model and pooled into a single analysis young asexual complexes undergoing the creation of new clones together with profoundly diversified asexual clades, which already meet the definition of a species and do not even have close sexual relatives (e.g. [ 16]).
To pool such results, the reviewer has three options: to pool sensitivities and specificities for all relevant cut-off points, to pool the AUCs, or to model and pool the ROC curves themselves.
The estimated coefficients of the LUR models by city and pooled across cities are available in the Supplemental Material, Tables S2 S6.
We identified urinary albumin creatinine ratio, but not eGFR, as an independent associate of LEA in the multivariable models involving FDS1 and pooled data, consistent with previous studies reporting albuminuria as an important risk factor [ 20, 44, 45].
Two analytical approaches were used to account for site: one was to additionally adjust for study site in the regression model as described above, and the other was to construct site-specific regression models and pool the estimates using meta-analysis.
The changes from baseline in efficacy variables were analysed using an ancova model, with treatment and pooled centre as the classification factor and baseline as the covariate.
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