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However, based on results so far obtained in animal models and pilot clinical studies, one can affirm that the bone tissue engineering approaches, although successful in most cases, need further validation before a wide application in clinics.
In animal models and pilot studies with BE, BE-based oleogel, or triterpene birch bark extract, no severe adverse effects have been observed.
Rapamycin has been found effective for systemic lupus erythematosus and systemic sclerosis in animal models and pilot clinical trials [ 53- 57].
Previous studies in mouse models and pilot epidemiology studies have demonstrated that inherited polymorphisms are associated with inherited risk of tumor progression and poor outcome in human breast cancer.
Data from animal models and pilot clinical studies have indicated that native GLP-1 may have cardioprotective effects in the setting of ischaemia, or following ischaemic injury [ 37, 38, 41, 42].
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Agreement between the hydrodynamic model and pilot experimental points is shown to be fairly good.
It is therefore possible to find the best positioning scheme for the desired block size, BE model, and pilot sequence with a computer search.
Two of the dynamic data sets are used for model validation and the results shows adequate agreement between model and pilot plant data.
We conducted qualitative interviews with patients, families and staff, plus a literature review to model and pilot the service.
Rolling out AUDIT-C screening in general practice requires a comprehensive cost-effectiveness model and pilot evaluation, and our preliminary results suggest that such research may be warranted.
Through the modelling and piloting, we were able to test the mechanisms for patient identification and recruitment.
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