These studies differ significantly regarding time span, data frequencies, modeling, and methodological aspects, their findings being thus mixed but generating significant discussions due to policy implications.
The contribution of this paper lies in its addressing the VRPMPTW from a problem definition, modeling and methodological point of view.
HTA research takes three main forms: primary research (normally trials), evidence synthesis (systematic reviews, which usually include economic modelling) and methodological studies.
Carefully planned studies using multiple arthritis models and relevant methodological approaches are therefore imperative to further our understanding of the origin of joint pain.
The alignment between a target and its template is a current bottleneck in homology modeling approaches, and methodological improvements are needed to overcome this limitation, especially when sequence identity is low.
While the importance and difficulties of such models have been discussed by various authors during the past decade, mainly with a focus on how to describe or develop such models, several biological and methodological aspects have never been addressed so far, which are relevant for the application of models in risk assessment.
The structure of the model and additional methodological details are included in an additional file [see Additional File 1].
This analytical model and its methodological research approach involve three participating groups: researchers and other specialists; community members, such as common citizens, businessmen, farmers, fishermen, and miners; and decision makers in health interventions.
Each measure was explored on the basis of their i) theoretical framework (was there a definition of what was being assessed and was it part of a theoretical model?) and ii) methodological development (what was the scaling strategy, how were the items generated and reduced, what was the response format and what was the scoring method?).
