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Since the sale, the 17-year-old company has toned down its controversial ads which had previously featured scantily clad models and led the New York Times to dub the company the "supremo of Super Bowl sleaze".
By analyzing metabolic pathways in numerous mouse models of cancer and in human cancer samples transplanted into mice, the team found that the browning of white fat "was consistent in all of these models and led irreversibly to cachexia," says study co-author Erwin Wagner, a cancer biologist at CNIO. "This process is likely happening in these patients.
This observation contrasts with the predictions of clonal turnover/decay models and led the authors to the conclusion that the ages of clones are not affected by the stochastic component (i.e. clonal recruitment rate) to a large extent.
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Alyssa Davis, former Health Advisor at Concern Worldwide Burundi, conceptualized the MOH-led model and led its initial field implementation.
Numerical analysis of such structures require highly discretized finite element models and leads to extensive computations.
Combining such models is much easier than of precursor models and leads to new model properties and predictions.
This is in contrast to a clinically irrelevant, proteinaceous ovalbumin, which is used in many asthma-related animal models and leads to tolerance in the absence of systemic sensitization [ 73– 73].
This assumption is the main limitation in our model and led to the further assumptions that AIV circulation did not previously occur in halt meshes, or that infected birds became immunized and cannot be re-infected during their movements.
Initial reconstitution experiments using liposome containing recombinant SNAREs supported this model and led to the hypothesis that SNAREs by themselves are sufficient to account for the membrane fusion process [42].
RS analysed the data, developed the model and led the writing of the manuscript.
EB designed the study, undertook the statistical modeling and led the writing.
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