Of these, the only two in vivo studies, one exploring an intranasal infection model in mouse [32] and the other an intradermal model [33], came to different conclusions regarding the TLR2-dependence of mouse susceptibility to F. tularensis LVS infection.
Mutants lacking the gene/genes of each of the three regions were constructed but each of the mutants showed full virulence in the mouse model, killing mice at an intradermal dose of 10 CFU with no extended time to death compared to SCHU S4 (Table 3).
For induction of chronic homologous CIA, 8-week-old DBA/1 (H-2q) male mice were used (Harlan UK Limited) and immunized following a protocol adapted from the previously described model [ 27], using an intradermal injection at the base of the tail of 100 μg murine type II collagen emulsified in Freund's complete adjuvant followed by a boost of 100 μg of murine type II collagen given at day 14.
In this study, we investigated the anti-angiogenic activity of a tumor cell vaccine in an intradermal tumor model.
To establish an intradermal tumor model, 5 groups of mice (3 in each group) were vaccinated with TCL, TCL-NS, TCL-DT, TCL-M2, or DT-TCL-M2 three times at weekly intervals.
inoculation of mice, and produced intermediate sized lesions between the deletion mutant and the WT viruses in a intradermal model of infection51.
In the present study, we applied an intradermal ET-1 sensitization model to induce mechanical hyperalgesia in healthy subjects.
After insertion, MNs could be directly implanted in the dermal layer as an intradermal (ID) depot to allow a sustained release of the model antigen ovalbumin (OVA) for up to 28 days.
Five patients received an intradermal administration of 1.0 nmol of 99mTc-labeled Lymphoseek and five patients received an intradermal administration of filtered [99mTc]sulfur colloid (fTcSC).
Six subjects received an intradermal administration of TcSC; SLN mapping was performed on five subjects within 18 to 26 h.
