The next section therefore describes how a cost model (also implemented in the tool) can be used to select the best option based on the charges made by the cloud providers.
Importantly, the previous model also implemented a hypothetical projection regarding the use of ustekinumab, as this biologic was just becoming available in the Greek market and data on its real-world use were not available for Greece.
In addition to photoionization, the hybrid model also implements electron impact ionization reactions, and charge-exchange (CX) reactions between the neutral corona atoms and exospheric/solar wind protons.
As an example of an intermediate between the fully periodic and fully random models, we also implemented a Markov model of discrete drug-taking and drug-missing states, which we call "adherence states".
Finally, branch-site models were also implemented, comparing by an LRT the null model MA with ω fixed to 1 and the alternative model MA with ω estimated [ 42, 43].
For an additional level of comparison, another soft clustering scheme based on Gaussian mixture models was also implemented.
Co-pollutant logistic models were also implemented to evaluate potential confounding by co-pollutants.
Shared random-effects models are also implemented in the JM R package [ 59] (Table 4).
Branch [ 43] and branch-sites [ 42, 44] models were also implemented in order to test for changes in selective constraint along lineages leading to the more divergent sequences, LWS5 and LWS6 (Fig. 3).
Considering that the number of SNPs is relatively large compared to the number of animals with phenotypes, all models were also implemented after performing principal component analysis (PCA) to reduce the data dimensions while still explaining 97% of the variance of the SNP genotypes in the data.
