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The arrival of more and more new models also contributes, Mr. Ditlow said.
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Genetically modified mice provide models for Alport syndrome evolving to renal failure that have resulted in clinical recommendations, polycystic kidney disease models that have provided clues for the development of tolvaptan, that was recently approved for the human disease in Japan; and animal models also contributed to target C5 with eculizumab in hemolytic uremic syndrome.
Knock-in models also contributed to our understanding of HD.
Not only are the predictions shown to be in good accord with the experiments, but the model also contributes to the understanding of the extrusion process by identifying the variables and parameters to which the system is most sensitive, and thereby becomes a potentially powerful design tool.
This model also contributes to the explanation of the response of var genes to stress exposure (black arrow 4 in Fig. 7): Stress inducing conditions would cause induction of var genes regardless of their subtype classification or their chromosomal position.
The current COPE model also contributes to the tendency toward parallel systems.
This model also contributes to the effective compartmentalization of many family proteins.
In addition to the exploration of genes that are known to impact human health, the powerful zebrafish model also contributes to the discovery of previously unidentified disease genes.
Students' reflections on their prior discussion regarding an initial cost model also contributed to their movement towards a more comprehensive model.
Each of the associated SNPs in the logistic regression model also contributed positively in the neural network.
JA, who was one of the contributors for the original UK model, also contributed to a crucial review of this manuscript.
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