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For cancers such as ovarian, gastric and colon, which metastasise within the peritoneal cavity, it is paramount that the in vitro models adequately reflect the processes that occur during peritoneal dissemination.
By ensuring adult models adequately reflect observed PK data, the workflow provides an appropriate framework by which preexisting PK data from adults can be leveraged for the purposes of pediatric model development.
Conversely, when the BRCAPRO and Myriad models adequately reflect the cancer history of the families with low scores, one has to think of a possible confounder whenever the high score in one of the families is discordant with the rest for a particular UV.
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A new method is presented which is designed to investigate whether laboratory test data used in the development of vehicle emission models adequately reflects emission distributions, and in particular the influence of high-emitting vehicles.
While remarkably pervasive, the empirical reality of global health does not always lend itself to readily identifiable Principals and Agents, nor does this model adequately reflect the multiple accountabilities that actors contend with [ 9, 10].
A one-box model adequately reflected measured number concentrations (r2 > 0.99).
Following this, we describe some approaches that will help decide whether the statistical model adequately reflects the survivor patterns observed.
We suggest that this four-dimensional model adequately reflects the multidimensionality of the childbirth experience and can be used as a tool to identify women with negative experiences and for evaluating efforts to improve the quality of childbirth care.
It was suggested that underestimates of viral divergence times may be caused by limitations of the models to adequately reflect evolutionary events.
However, a prerequisite for tailoring outcomes to individual patients is the availability of robust predictive models that adequately reflect outcomes in routine practice settings.
Identification of the actual mechanisms involved should eventually lead to the development of risk assessment models that adequately reflect the unique biological and toxicological characteristics of different species-chemical combinations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com