Sentence examples for models activation of from inspiring English sources

Subsequently, in numerous animal models, activation of the vitamin D pathway with calcitriol, the active component of vitamin D, or its analogues reduced tumour development and growth (Krishnan et al, 2010; Mehta et al, 2012; Pereira et al, 2012).

In different tumor models, activation of PPARα by agonists blocks tumor growth and angiogenesis by reducing production of proangiogenic factors such as VEGF or epoxyeicosatrienoic acids [23] [25].

In all models, activation of PPARα significantly altered processes related to various aspects of lipid metabolism.

In both models, activation of Sir2 leads to increased rDNA silencing and a consequent reduction in recombination between rDNA repeats; this reduces the formation of extrachromosomal rDNA circles (Sinclair & Guarente, 1997) and so retards aging.

In contrast to other worm neurodegeneration models, activation of the Sirtuin, SIR-2.1, was not required, as sir-2.1; dnj-14 double mutants showed full lifespan rescue by resveratrol.

However, while Akt1 is required for efficient tumour formation in MMTV-ErbB2 mouse models, activation of Akt1 alone is not sufficient for mammary tumourigenesis [ 11, 12] indicating that other pathways downstream of ErbB2 activation are important for tumour formation.

According to the present model, activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.

For example, it has been demonstrated that, in a rat experimental headache model, activation of meningeal TRPV1 receptors by capsaicin resulted in the release of CGRP from trigeminal afferent nerves.

Since lymphopenia is induced by irradiation in our model, activation of the cross-presenting APCs could by-pass the need for CD40 engagement by CD4+ T helpers.

In our model, activation of p38 appears to be critical for H5N1-associated redox signalling since p38 inhibition had been shown before to mimick effects of the antioxidant N-acetyl-cysteine (NAC) [34].

In a logic model, activation of nodes is defined by a set of operators.