The interpretability of these models across all biological problems is, however, limited by prediction accuracy at this level.
It is likely that the accuracy of niche models varies systematically across biological groups [30].
We propose a novel method for DE analysis across replicates which propagates uncertainty from the sample-level model while modelling biological variance using an expression-level-dependent prior.
This paper provides an assessment of the toxicological basis of the hormetic dose response relationship including issues relating to its reproducibility, frequency, and generalizability across biological models, endpoints measured and chemical class/physical stressors and implications for risk assessment.
Pre- and postconditioning studies with rigorous study designs, using multiple doses/concentrations along with refined dose/concentration spacing strategies, often display hormetic dose/concentration response relationships with considerable generality across biological model, inducing (i.e., conditioning) agent, challenging dose treatment, endpoint, and mechanism.
Given the evidence across biological levels and species models, we hypothesized that perturbation of MRG15 function through genetic mutations or common alleles might be at the root of some cases of FA and/or BrCa.
If so, such covariance could be used to predict contacts across interfaces and assemble models of biological complexes.
Although in its nascence, agent-based modelling has been utilized to model biological complexity across a broad range of biological scales (from cells to societies).
Developing models for biological processes.
Membrane proteins perform crucial communication functions across biological membranes.
