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Although these models accurately recapitulate most of the disease features of EHF, practical and ethical concerns limit their use, including nonreproducible genetic backgrounds, cost, animal availability, and reagent availability.
Although these models accurately recapitulate most of the disease features of EHF, practical and ethical concerns limit their use, including non-reproducible genetic backgrounds, cost, animal availability, and reagent availability.
The models accurately recapitulate the complex topologies of the proteins.
Similar(57)
A major hurdle to progress is the lack of animal models accurately recapitulating the behavior and neuropathological features of human tumors [108].
Our model accurately recapitulates short-term behavior and cell-to-cell variability under basal and activated conditions of autophagy.
No current experimental model accurately recapitulates bone metastasis, so researchers often choose a model having a specific characteristic relative to the system they are studying.
This model accurately recapitulates the metastatic latency observed clinically, permitting the development of therapeutics that target metastatic cells during dormancy prior to activation.
Moreover, the similarity with the previously identified expression patterns in human disc degeneration suggests that our model accurately recapitulates natural disc degeneration.
Consequently, this mouse model accurately recapitulates features of GACI, a disease that is usually lethal within the first 6 months of life.
This novel double-mutant mouse model accurately recapitulates the symptoms of human muscular dystrophies and could be used for further studies of the mechanisms involved in DGC destabilization.
While the model accurately recapitulates human disease in terms of pathology and specific genetic events, the r esulting tumors likely do not represent the large number of genetic and molecular changes that occur within any given human glioma.
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