However, due to the limitations of experiment, such as the multiple transcriptional time lags and lack of data points, the traditional linear models lead to misleading modeling.
"The animal models are misleading," he said.
Opal and Cross (1999) summarized already then 'It has become painfully evident that animal models provide misleading and overly optimistic estimates of the survival benefit of specific antisepsis drugs when compared to clinical efficacy in actual human sepsis'.
The fact that there is very little compensatory decline in incidence when women are no longer screened, in Norway as well as in other countries (Jørgensen and Gøtzsche, 2009), proves that model-based lead-time models are seriously misleading.
Proponents of the sciences tend to argue that a "two cultures" model is misleading and out of date.
However, the most popular approaches to modelling respondent-specific effects (random effects models) potentially are misleading.
Elizabethan writers, anxious to follow Classical models but misled by a false etymology, believed that satyre derived from the Greek satyr play: satyrs being notoriously rude, unmannerly creatures, it seemed to follow that the word satyre should indicate something harsh, coarse, rough.
Hypoxia and necrosis may have a profound influence on the physiology of Mtb, rendering a study of host-pathogen interactions in non-hypoxic models misleading [20].
Hence, whenever interventions target or affect cellular energy metabolism [14, 15], results obtained in mouse models may be misleading.
This study shows that previous claims on efficiency gains via ICR, using highly-simplified models, may be misleading.
