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We evaluated three different models: a clinical model including seven bed-side characteristics, the clinical model plus PCT, and a PCT only model.
Though several studies have demonstrated elevated levels of multiple IAPs in an array of human cancers as well as tumor models, a clinical correlation could not be established for many of them.
This paradigm models a clinical phenomenon of an excessive, binge-type food consumption, where individuals repeatedly seek out and consume large amounts of highly palatable food, in a brief and discrete period of time (Weltzin et al. 1991).
After the demonstration that adding afuresertib to bortezomib promotes cell death and inhibits phosphorylation of downstream proteins in preclinical models, a clinical trial had been designed to evaluate MTD, safety, tolerability, and response rate of afuresertib, bortezomib, and dexamethasone combination.
Following the successful treatment of macular degeneration with hESC-derived retinal pigment epithelium in animal models, a clinical trial has been initiated to treat this disease with hESC-derived retinal pigment epithelium cells [ 9].
Following proof-of-concept in animal models, a clinical development program was launched that consisted of two observational studies, three open-label interventional studies and a long-term follow-up review analysis.
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Three multivariate logistic regression models were developed: the first model was a clinical model that included clinical variables; the second model was based on the RV/LV ratio and laboratory variables; the final model was based on SIRS (Table 2).
In group 1 (localized osteomyelitis model), a clinical strain of S. aureus (52/52A/80, donated by Dr. Mader) was applied.
The framework was applied to model a clinical guideline for gestational diabetes mellitus and to derive a prototype that executes the guideline on a smartphone.
On the basis of data from a preclinical mouse xenograft model, a clinical trial was conducted involving patients with operable breast cancer stage I to stage IIIA.
Three epoxy resin (Ramses medical products factory, Alex, Egypt) completely edentulous mandibular models representing a clinical situation were used as definitive casts.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com