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An example of in vitro adult brain disease modelling using patient specific material is that of Parkinson's disease-causing LRRK2 mutation carrying neurons having increased vulnerability to oxidative injury as well as morphological defects [ 68, 69].
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In the same year, Moretti et al. reported long-QT syndrome type 1 modelling using patient-specific iPSC-CMs that exhibited electrophysiological properties of this disorder [ 138].
For modelling issues, we used patient's medians throughout.
3 Economic modelling used placebo controlled trials to justify their use in patients with active rheumatoid arthritis who were resistant to methotrexate.
Further research is required in the following areas (i) further modelling studies using alternative modelling methods such as individual patient sampling techniques could be used to account for heterogeneity in the patient population, so that factors such as tumour growth rate, tumour characteristics and the variability in individual patients' serial test results could be assessed.
Conversely, Lisowska [ 23] applied their modelling technique to over 47000 genes using 127 patients.
This is consistent with accuracies of similar modelling efforts using the Landsat sensor [ 16].
Whilst this is an individually randomised controlled trial we will use multi-level modelling with patient as the 1st level and practice as the 2nd level, plus we will test for clustering at the clinician level as the outcome could be seen as a clinician behavioural measure.
The modelling code used in the robustness models is available upon request from the corresponding author.
(3) Another modelling approach used in this study is the generalised additive models (GAMs).
We also highlight the complementarity of the modelling approaches used in our case studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com