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It is concerned with the development of new computational tools such as databases and modelling systems, but it also encompasses research into the similarities and differences between artificial and natural intelligence.
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This study used GRPr-targeted radiopeptides and a GRPr-positive xenograft model as model systems, but we assume that the results also apply to other (radio peptides that target receptors highly expressed on solid tumors.
Despite the extensive attention on the factors that determine the specific packing of SSEs in certain forms, most of the above discoveries were made in simple soluble model systems but not natural proteins.
Hsp90 has been studied widely in animal and yeast model systems, but little is known by comparison about plant Hsp90.
These findings also help to reconcile the disparate findings that immune therapeutic approaches can be used successfully in preclinical model systems but have yet to achieve successful responses in the vast majority of patients by demonstrating the importance of the tumor hypoxic environment in markedly inducing the immune suppressive properties of the GBM.
On one level, individual genes can be prioritized for analysis by gene knockdown in animal model systems, but we also hope that the dataset can be utilized to revisit previously generated gene knockouts in mice to screen for subtle defects in orofacial formation and function that may not have been recorded.
Cell lines are critical model systems but cell line annotations have been heterogeneous and sparse.
In contrast, highly correlated wave function approaches provide accurate transition energies for model systems but are hardly applicable to real-life cyanines and BODIPY.
The NEK kinases have been relatively little studied in model systems, but several appear to be involved in cell cycle [ 68] and cytoskeletal functions [ 69, 70].
Several other transcription factors have been linked to the ENS in model systems but have unexpected mutant phenotypes or an unknown relevance to human disease.
This strategy, known as spermatogonial stem cell transplantation, has been successful in mice and other model systems, but has not yet been applied in humans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com